Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p194 | (1) | WCRB2014

High-throughput screening revealed a clinically relevant drug to induce sperm motility

Cochrane Clair , Ruso Halil , Hope Anthony , Clarke Rosemary G , Barratt Christopher , da Silva Sarah Martins

Introduction: Sperm dysfunction is the commonest cause of infertility, yet there is currently no drug a man can take, or be added to his sperm in-vitro, to improve fertility. The rationale of drug discovery research is to find a drug which increases sperm motility and success of ART. Despite limitations in understanding of sperm physiology, it is acknowledged calcium is central to motility and function. Validated high-throughput screening of compounds from University ...